基于氧化亚铜纳米立方体的无酶葡萄糖传感器的研制

The preparation of nonenzymatic glucose sensor based on the Cu_2O nanocubes

采用多元醇水热法制备单晶氧化亚铜纳米立方体并用透射电镜观察其形貌．将其分散在Nation溶液中修饰玻碳电极制成电化学传感器，用于葡萄糖的直接电化学测定。考察了该传感器的电化学特性，同时探讨了pH、工作电位等条件对传感器性能的影响。实验结果表明：在电位为500mV时，该传感器检测葡萄糖的线性范围为9．9×10^-5～1．14×10^-2mol／L，检测下限为3．3×10^-5mol／L。线性相关系数为0．991。该方法快捷、灵敏、分析性能好，操作简便。将其应用于血清中葡萄糖含量的测定，结果令人满意。

Single-crystalline Cu20 nanocubes were synthesized with assist of PEG-400. An electrochemical sensor was prepared for the determination of glucose using Cu20 nanocubes and Nation to modify glassy carbon electrode. Experiment conditions such as electrolyte and applied potential have been optimized. The results show that the electrode can direct response to glucose at potential ofO.50 V vs. SCE with wide linear range of 9.9×10^-5 to 1.14×10^-2 mol.L and the detection limit of 3.3×10^-5 mol/L. The sensor has good stability, long lifetime and simple production procedure. The sensor was applied in the determination of glucose in serum and the result was satisfactory,