肝脏氧化调节因子及其对动物采食调节机制的研究进展

Research Progress on Regulatory Factors Related with Hepatic Oxidation and Their Effects on Feed Intake

合理的采食量是优化奶牛等各种动物消化和吸收营养物质的前提,是提高动物生产性能和健康状况的关键因素。肝脏氧化是调节动物采食量的重要代谢途径,生能物质可通过提高动物肝脏细胞能量状态,进而降低肝细胞膜电位和细胞膜信号分子释放,最终抑制动物采食。而此代谢途径可被非营养性(2,5-脱水-D-甘露醇,棕环氧酸甲酯等)和营养性物质(2-脱氧葡萄糖、丙酮酸盐等)调控,进而影响动物的采食量。本文就非营养性和营养性物质对动物肝脏氧化代谢和采食量调节效果及机制进行综述。

Great digestibility and nutrients absorption of the mammalians could be achieved based on the optimized feed intake, and play key roles in improving performance and health status of the animals. Hepatic oxidation is a key metabolic pathway in food intake regulation of the animals. Fuels oxidized in the liver could enhance hepatocytes energy status （ATP content）. Hepatocytes and satiety/hunger signals are transmitted through hepatic vagus afferent nerve, and finally result in change in eating behavior of the animals. This metabolic pathway is affected by both of non-nutritional and nutritional substrates. This review briefly introduced the effects of nutritional and non-nutritional substrates on hepatic oxidation regulation and further feed intake of the animals as well as the mechanisms involved.