妊娠期高血压疾病及同型半胱氨酸、超敏C反应蛋白相关性的临床研究

Clinical Research on Correlation between the Concentration of Serum Homocysteine and High-sensitivity C-reactive Protein with Hypertension Disorders in Pregnancy

目的:观察血清同型半胱氨酸(Hcy)及超敏C反应蛋白(hs-CRP)在妊娠期高血压系列疾病患者中的差异。方法:选择妊娠期高血压疾病患者180例。其中妊娠期高血压疾病60例,子痫前期轻度60例,子痫前期重度60例,并随机选取同期的正常晚期妊娠60例为对照组。并对子痫前期轻度、子痫前期重度患者入院当天,硫酸镁治疗后第1、3、5、7、28天血清Hcy、hs-CRP浓度检测,选取同期先兆早产硫酸镁治疗患者60例做对照。结果:妊娠期高血压病患者血浆Hcy和Hs-CRP水平随着病情加重水平不断升高,差异有显著性(P均<0.05);经过硫酸镁治疗后子痫前期轻度、子痫前期重度患者血清Hcy、hs-CRP水平逐渐降低,与先兆早产组比较差异有统计学意义(P均<0.05)。结论:妊娠期高血压病患者血浆Hcy和Hs-CRP水平随着病情发展不断升高,密切监测其变化,对妊娠期高血压疾病的预防、诊疗及动态监测有着重要的临床价值。

Objective：To investigate the difference between homocysteine （Hcy） and high-sensitivity C-reactive protein （hs-CRP） in the hypertension disorders in pregnancy.Methods：180 HDP patients selected：60 patients of them with gestational hypertension,another 60 patients of them with mild preeclampsias pregnancy and balance 60 patients with severe preeclampsias;60 normal late-term pregnancy women selected as control group.Concentration of Hcy and hs-CRP was detected on the patients with mild preeclampsiaspregnancy and these with severe preeclampsias on the day of admission;same detection was performed on same patients1 day,3 days,5 days,7 days,28 days after treatment of Magnesium sulfate;60 threatened premature labor patients by treatment of magnesium sulfate were selected as controls.Results：The values of Hcy and hs-CRP of HDP patients were on the rise with patients condition becoming worse （P〈0.05）. The values of Hcy and hs-CRP were gradually on the decrease after treatment of Magnesium sulfate given to the patients with mild preeclampsiaspregnancy and these with severe preeclampsias.Deference gets statistical significance.Conclusion：The levels of plasma Hcy and hs-CRP in patients with female climacteric hypertension are constantly on the rise with progression of disease.Close watch on the variations of these levels would get important clinical values in the respects of prevention,treatment and ambulatory monitoring on HDP.