178例药品不良反应报告分析

Analysis of ADR in 178 Cases

目的：分析辽阳市二院2009年7月-2010年11月的178例不良反应（ADR）报告，为临床安全合理用药提供参考。方法：对178例ADR报告分别从药物种类、给药途径以及患者年龄、性别等方面进行统计分析。结果：178例ADR中，抗生素94例占52.8%，循环系统药物36例占20.2%，中药注射剂14例占7.9%。ADR的临床表现以皮肤损害为最常见，有67例，占37.6%。结论：发生ADR最多的是抗菌药物，其中以头孢菌素类占首位，其次是喹诺酮类，提示临床应根据患者具体情况，合理使用抗菌药物。加强对中药注射剂的质量监测，要慎用。用药前要注意询问患者的过敏史，用药后要认真观察，尽量避免或减少药物ADR的发生。

Objective：To analyze 178 cases of ADR which were reported by the second people＇s hospital of Liaoyang city from July 2009 to November 2010,in order to provide a reference for the rational use of drugs of clinical safety.Methods：To analyze 178 cases of ADR reports respectively from the type of drug, route of administration,and the patient＇s age,gender etc.Results：Among 178 ADR cases,94 cases of antibiotics accounted for 52.8%,36 cases of circulatory system drugs accounted for 20.2%, traditional Chinese medicine injections of 14 cases （7.9%）. Skin lesions is the most common clinical manifestations of ADR, 67 cases, accounting for 37.6%.Conclusion：ADR Occurred by antimicrobial agents is the most, cephalosporins accounted for the first,fol owed by quinolones, this prompts clinical rational use of antimicrobial drugs in accordance with the specific circumstances of the patients.Strengthen the monitoring of the quality of traditional Chinese medicine injection and it should be used with caution.Ask the patient＇s al ergy history before medication ,observe careful y after medication , to avoid or reduce the occurrence of ADR.