抗有丝分裂相关抗原自身抗体临床意义初步分析

Clinical significance of mitosis specific autoantibodies

目的为研究抗细胞分裂期相关抗原自身抗体(MSA)与临床疾病的关系。方法采用间接免疫荧光法检测患者血清中的自身抗体,分析抗MSA阳性住院患者的临床资料。结果 4339例住院患者中87例检测出MSA,总阳性率为2.03%,其中36例为抗中心粒抗体阳性(0.83%),35例为抗着丝点抗体阳性(0.81%),13例为抗纺锤体抗体阳性(0.30%),6例为抗中间体抗体阳性(0.14%)。34例(39.08%)同时合并抗细胞核或细胞浆抗体阳性。所有明确诊断的病例中,风湿性疾病28例(32.18%),感染性疾病20例(22.99%),肿瘤性疾病3例(3.45%),其它种类疾病(皮肤、肾、消化、血液系统等)36例(41.38%)。风湿性疾病中MSA滴度显著高于其它疾病(P<0.01)。结论 MSA临床上少见,以抗中心粒抗体与抗着丝点抗体为主,可发生于多种临床疾病,高滴度水平与风湿性疾病有相关性。

Objective To study the association of mitosis specific autoantibodies （MSA） with various diseases in clinic. Meth- ods MSA in serum was detected with indirect immunofluorescence. Clinical data of patients with MSA positive was analyzed. Results Of the 4339 inpatients, 87 cases were positive with MSA and the positive rate was 2.03%. The anti - neutrophil an- toantibodies were positive in 36 patients（0.83% ）, anti - centromere autoantibodies were positive in 35 cases （0.81%）, anti - spindle apparatus autoantibodies were positive in 13 cases （0.30%）, anti - intermediate autoantibodies were positive in 6 ca- ses （0.14%）. Of the 87 patients, 34 cases （39.08%） were positive with anti - nuclear or anti - cytoplasmic autoantibodies. There were 28 cases with rheumatic diseases （32.18%）, 20 cases with infectious diseases （22.99%）, 3 cases with carcinoma diseases （3.45%） and 36 cases with other diseases （41.38%）. The titer of MSA was higher in rheumatic diseases than that in Other diseases. Conclusion MSA were quite rare in clinic, most were anti - neutrophil and anti - centromere autoantibodies. MSA could appear in various diseases. MSA of high titer was corrdated with rheumatic diseases.