急性心肌梗死合并应激性高血糖患者心功能与并发症的临床观察

Clinical observation cardiac function and complications in patients with acute myocaredia infarction combined with stress hyperglycemia

目的观察急性心肌梗死(AMI)合并应激性高血糖患者血清N末端B型钠尿肽原(NT-proBNP)水平变化及并发症的发生,探讨应激性高血糖对心功能与并发症的影响。方法选择45例AMI合并应激性高血糖患者(观察组)和39例AMI非应激性高血糖患者(对照组)为研究对象。血清NT-proBNP检测采用电化学发光免疫分析(ECLIA)法,观察两组患者住院期间并发症的发生情况。结果观察组患者血清空腹血糖和NT-proBNP水平[(10.08±0.73)mmol/L、(1597.6±508.9)pg/ml]显著高于对照组[(4.91±0.85)mmol/L、(601.4±175.3)pg/ml],P<0.01,住院期间观察组心血管事件发生率(64.4%)也显著高于对照组(28.2%),差异有统计学意义(P<0.01)。结论 AMI合并应激性高血糖患者心功能损害严重,且易发生心血管事件,血清NT-proBNP水平检测可判断心功能损害程度及观察临床疗效。

Objective Through the observation of the serum NT-proBNP level change and complications in patients with a- cute myocard infarction （AMI） combined with stress hyperglycemia （SHG）, to discuss the effect of SHG on cardiac function and complications. Methods Forty-five patients with SHG （observation group） and 39 AMI patients without SHG （control group） were selected. Serum NT-proBNP was detected by ECLIA, and the complications between the two groups were compared. Results The serum FBG and NT-proBNP level in observation group [ （ 10. O9± O. 73 ） retool/L, （ 1597.6 ± 508.9 ） pg/ml ] were significantly higher than those in control group [ （4. 91 ± 0. 85 ） mmol/L, （601.4± 175.3 ） pg/ml ] , P 〈 0. 01, and the inci- dence of cardiovascular events in observation group （64. 4% ） was significantly higher than that in control group （28.2%）, P 〈 0. 01. Conclusion AMI patients combined with SHG has a serious heart dysfunction, and apt to suffer from cardiovascular e- vents, serum NT-proBNP level detection could diagnose the cardiac damage degree and observe the clinical efficacy.