氟哌噻吨美利曲辛片辅助治疗肠易激综合征的Meta分析

Meta analysis of flupentixol and melitracen tablets assisted treatment of irritable bowel syndrome

目的系统评价氟哌噻吨美利曲辛片辅助治疗肠易激综合征（IBS）的效果。方法通过中国知识资源总库全面检索有关氟哌噻吨美利曲辛片联合常规药物治疗IBS的文献，采用Jadad量表进行质量评分，用RevMan5．0及Stata软件进行统计分析。结果纳入Meta分析的文献共计12篇，包含12项研究，均为随机对照试验，共纳入1384例病例，其中治疗组704例，对照组680例，异质性检验结果：x2=25．48，P=0．008，I2=57％，故选用随机效应模型，其合并艘值为1．39，95％CI为1．27—1．53，表明氟哌噻吨美利曲辛片辅助治疗IBS确实能提高有效率，与对照组之间差异有统计学意义（P〈0．05）。结论与常规治疗组比较，联用氟哌噻吨美利曲辛片可明显提高IBS的疗效。

Objective To investigate the therapeutic effect of flupentixol and melitracen tablets for irritable bowel syndrome （ IBS ）. Methods Relevant concerned with the therapeutic effect of Flupentixol and melitracen tablets and routine medicine were reviewed by China national knowledge infrastructure. All reviewed literatures were accessed by Jadad quality scale. Statistic data was analysed by RevManS. 0 and Stata~ Results Twelve articles of randomized controlled trial were collected. Among these study, there were 1384 patients, which divided into treatment group （ n = 704 ） and control group （ n = 680 ）. The results of heterogeneity showed that X2 = 25.48, P = 0. 008, I2 = 57%. Therefore the random effects model was selected. The combined relative risk is 1.39 and the 95% C1 was 1.27 - 1.53. Conclusion Compared with traditional treatment, flupentixol and melitracen tablets can obviously improve the therapeutic effect of IBS.