摘要
目的:评价miR-21的高表达与乳腺癌预后的相关性。方法:检索PubMed,MEDLINE,EMBASE,Web of science,维普,CNKI数据库,收集从建库至2013年9月期间关于miR-21的高表达与乳腺癌预后相关性的文献,用meta分析方法评价miR-21的高表达是否与乳腺癌的预后相关。结果:共纳入4篇文献(总计548个病例),总生存率(OS)HR的合并值为1.61(95%CI:1.09至2.37,P<0.05)。结论:miR-21的高表达是乳腺癌预后的一个危险因素。
Objective： To evaluate the correlation between the high expression of miR- 21 and the prognosis of breast cancer. Methods： Eligible studies which studied the correlation between the high expression of miR - 21 and the prognosis of breast cancer were collected through searching PubMed , MEDLINE, EMBASE, and Wed of science,VIP,CNKI databases. A meta analysis method was used to evaluate whether the high expression of miR - 21 has an association with the prognosis of breast cancer. Results： A total of 4 studies （548 cases） were involved in this meta- analysis. For overall survival （OS）, the pooled hazard ratio （HR） of higher miR - 21 expression in cancerous tissues was 1.61 （95%CI： 1.09 - 2.37,P 〈 0.05}. Conclusions： High expression of miR - 21 is a risk factor of breast cancer.
出处
《激光杂志》
CAS
CSCD
北大核心
2013年第6期76-77,共2页
Laser Journal
