重型肝炎患者预后与检验指标关系分析

Relationship between prognosis and test indicators among severe hepatitis patients

目的 分析并筛选影响重型肝炎预后的相关检验指标因素，明确其与患者预后的相关关系，为重型肝炎的临床防治提供参考。方法 采用回顾性分析方法对2009年3月—2013年3月厦门大学附属第一医院杏林分院感染科接受诊治的重型肝炎患者294例作为研究对象，采用单因素分析和多因素logistic回归分析法对影响其预后的相关检验指标进行统计分析。结果 在调整性别、年龄、分型及合并症等混杂因素后，多因素logistic回归分析结果表明，凝血酶原时间（OR=2.474，95%CI=1.172-4.793）、血小板计数（OR=1.118，95%CI=1.123-2.672）、尿素氮（OR=1.436，95%CI=1.011-2.874）和病毒DNA载量（OR=1.925，95%CI=1.117-3.018）为重型肝炎患者预后的主要影响指标。结论 凝血酶原时间、尿素氮、血小板计数和病毒DNA载量是影响重型肝炎预后主要检验指标。

Objective To analyze the test indicators influencing the prognosis of severe hepatitis and to determine their relations with the prognosis of the patient and to provide reference for treatment of severe hepatitis. Methods A total of 294 medical records of severe hepatitis inpatients in a hospital from March 2009 to March 2013 were analyzed retrospectively.Univariate and multivariate logistic regression analyses were used to examine associations of test indicators with the prognosis of the severe hepatitis. Results After adjusting the confounding factors such as gender,age,and disease classification and complications,prothrombin time（PT）（odds ratio[OR]=2.474,95% confidence interval[95% CI]=1.172-4.793],platelet count（PLT）（OR=1.118,95% CI=1.123-2.672）,blood urine nitrogen（BUN）（OR=1.436,95% CI=1.011-2.874）,and viral DNA loads（OR=1.925,95% CI=1.117-3.018）were the main indexes related to prognosis of severe hepatitis. Conclusion PT,BUN,PLT and viral load are major test indicators affecting the prognosis of severe hepatitis.