影响大肠癌术后中医药治疗患者生存的基线预测因素分析

Analysis of Baseline Predictors in Patients Survival after Colorectal Cancer Operation with TCM Therapy

目的:在接受中医药治疗的大肠癌术后患者中探讨影响患者生存的基线预测因素。方法:采用回顾性队列研究,选择来自于2008年1月至2012年6月就诊接受中医药治疗的进展期大肠癌术后患者共113例,记录患者术前第1次测定的实验室检查指标,观察患者的术后生存情况。结果:经单因素分析,患者体质量指数(BMI)<20,有肝转移、腹膜转移,血红蛋白、红细胞计数低于正常值下限,白蛋白<35 g/L,癌胚抗原(CEA)、糖链抗原(CA)125和CA199高于正常值上限,中医药治疗晚于术后6个月等因素是影响中医药治疗大肠癌术后患者生存的预测因素(均P<0.05)。经逻辑回归分析,仅BMI<20和有肝转移具有统计学意义(均P<0.05)。结论:在接受中医药治疗的大肠癌术后患者中,基线BMI<20和有肝转移是预测患者生存的因素;患者尽早接受中医药治疗可能改善预后。

OBJECTIVE： To explore baseline predictors of survival in post-operation colorectal cancer patients who received TCM therapy. METHODS： Retrospective cohort study was adopted. 113 post-operation colorectal cancer patients received TCM therapy during Jan. 2008 to Jun. 2012. Lab indicators of patients were recorded before operation, and post-operational survival of patients was observed. RESULTS： By single factor analysis, the predictors of patient survival included BMI〈20, liver metastasis, peritoneal metastasis, hemoglobin, erythrocyte count lower than lower limit of normal, albumin〈35 g/L, CEA, CA125, CA199 higher than upper limits of normal, and initiating TCM therapy 6 months after operation （P〈0.05）. Only BMI〈20 and liver metas- tasis were statistically significant in logistic regression analysis（P〈0.05）. CONCLUSIONS：Among post-operation colorectal cancer patients who received TCM therapy, BMI〈20 and liver metastasis at baseline can predict patient＇s survival. TCM therapy as earlier as possible may be beneficial to prognosis.