摘要
本文应用^(126)I-UdR 释放法检测43例 Graves 病人外周血自然杀伤细胞(NK)活性,结果为66.50±10.66%,明显高于正常对照组(51.20±9.34%).治疗12～18个月的病人 NK 活性(59.04±8.84%)虽低于治疗前(67.60±9.44%)。但仍高于正常对照组.NK 活性与 T_3,T_4水平无关.本文提示 Graves 病人存在 NK 活性异常可能原发于该病的免疫功能紊乱.治疗后 NK 活性未完全恢复正常,可能是停药后复发的原因之一.
The peripheral blood NK activity of 43 cases with Graves' disease(GD)was determined by 125- UdR release assay. The results are as follows:(1)The NK activity was significantly higher that of the patients (66. 50±10. 66%) than that of the controls (51.20±9.34%). (2) The NK activity in the patients under treatment for 12～18 months (59. 04±8. 84%) was lower than that in those before treatment,but still higher than that in controls. (3) The NK activity was not associated with T_3 and T_4 level. The results suggest that the abnormality of NK activity may be primary to the autoimmune disorder of the disease. After treatment,the NK activity did not recover completely, which may be one of the causes of recurrence after drug withdraw.
