摘要
电镜观察8例胎儿及3例新生儿胃粘膜未分化细胞、幼稚粘液细胞及其他各种上皮细胞的超微结构特征及演变过程,发现最早期的壁细胞、主细胞和内分泌细胞除具有各自特征外,胞浆内均可能含有粘液颗粒,表明起源为同一干细胞。这种细胞在分化过程中一度出现的含微丝束的微绒毛,有别于小肠吸收细胞的微绒毛。作者认为胃粘膜干细胞在癌变过程中,能向各种不同方向分化,由此形成不同类型的胃癌。
Specimens of gastric mucosa taken from 8 cases of human fetus(the youngest, 2.5 months) and 3 newborn infants were studied under an electron microscope. The fine structural features of undifferentiated cells, immature mucous cells and other kinds of epithelial cells were described. Owing to the presense of mucous granules in the cytoplasm of the earliest parietal cells,zymogen cells and endocrine cells,it suggested that they originated from the same stem cells. The microvilll with microfilamentous cores which appeared in immature mucous cells early in their development were quite different from those of intestinal absorptive cells. The histogehesls of gastric carcinoma was discussed in light of the evidence revealed by this study. It suggested that all histologic types of gasric carcinoma were originated from the stem cell of gastric mucosa,which could differentiate'into different cell types during the course of malignant change. gastric mucosa;embryonic development;gastric carcinoma;histogenesis
