米索前列醇预防产后出血临床观察

Application of misoprostol to decrease the postpartum hemorrhage

目的 :观察口服米索前列醇对预防产后出血的效果。方法 :对 10 0例具有产后出血高危因素的病例随机分为米索前列醇组 (实验组 )和催产素组 (对照组 )。实验组于胎儿娩出以后立即肌肉注射催产素 10 u ,同时口服米索前列醇0 .4mg,对照组于胎儿娩出后立即肌肉注射催产素 10 u。比较两者的效果及副作用。结果 :实验组第三产程明显短于对照组 (P<0 .0 1) ,产后 2 h出血量明显少于对照组 (P<0 .0 1) ,用药前后对血压影响小 (P>0 .0 5 )。结论 :口服米索前列醇能有效预防产后出血 ,对血压影响小 ,尤其适用于高危孕产妇。

Objective:To observe the efficiency of oral misoprostol for decreasing postpartum hemorrhage.Method:100 cases with high risk of postpartum hemorrhage were randomly assigned to two groups either misoprostol or pitocin.The efficiency of misoprostol or pitocin and side effects of these two agents were compared.Result:The results demonstrated that misoprostol group had a singificant short course of the third delivery than pitocin group ( P <0.01),and significant less bleeding two hour after delivery than pitocin group ( P <0.01).Conclusion:It was also found that misoprostol acted nearly no influence on blood pressure ( P >0.05).Our study suggests that oral misoprostol can significantly decease postartum bleeding.