摘要
感染伯氏疟原虫(P.berghe ANKA株)小鼠,经矿泉“851”及与抗疟酮合用治疗后,腹腔巨噬细胞吞噬百分率和吞噬指数明显高于感染对照组(P<0.01)。两组药均能提高小鼠单核巨噬细胞系统(MPS)对碳微粒的廓清率,其K值与对照组相比,P<0.01,MPS活性的增强程度与其疟原虫的抑制率成正相关。
With '851' mineral spring and '851' plus antimalafen rats with infectious malaria (P. b. ANKA)were treated after treatment, the rate of phagoeytosis and phagocytic index significantly exceeded the control (P<0.01):the group of '851' was 37.10±1.91% and 0.67±0.16. The group of control was 20.03±1.57％ and 0.30±0.08. These two group of '851' and '851' plus antimalafen significantly raised the clearence rate of MPS (mononuclear macrophage system) to the carbon particles (P<0.01). The K values were 3.10 ±0.21 in infectious group, 6.04±0.31 in '851' group,5.084±0.32 in '851' plus antimalafen separately. The activity of MPS had positive correlation with inhibitory rate of plasmedium. The activity of phagocytosis was inhibited. The K value was 3.32±0.39 (P<0.05). With chioroquine plus mineral spring '851' the K value was 5.08±0.32 and the activity of phagocytosis raised (P<0.01).
关键词
疟原虫
抗疟酮
plasmodia
mineral spring'851'
antimalafen
chloroquine
