治伤Ⅰ号软膏治疗急性软组织损伤的实验与临床研究

EXPERIMENT AND CLINIC STUDY OF OINTMENT NO.Ⅰ FOR TREATING INJURY IN TREATMENT OF ACUTE SOFT TISSUE INJURY

目的 :观察治伤Ⅰ号软膏对急性软组织损伤的疗效和作用机理。方法 :①实验研究 :以七厘散为对照 ,分别观察二甲苯致小鼠耳廓肿胀度的影响、热板法对小鼠疼痛的影响。②临床研究 :以七厘散为对照 ,对急性软组织损伤的疼痛、肿胀和功能障碍等主要症状逐项分级评分。结果 :①该软膏对二甲苯致小鼠耳廓肿胀的急性炎症有抗炎作用 ,对热板法引起的小鼠疼痛有镇痛作用 ,与对照组相比均有显著差异 (P <0 0 5 )。②临床有效率与对照组相比有非常显著差异 (P <0 0 1) ;分级评分显示治疗组在镇痛、消肿和关节功能改善方面均优于对照组。结论 :治伤Ⅰ号软膏对急性软组织损伤有抗炎、镇痛作用 。

Objective:To observe the curative effect and mechanism of action of ointment NO.I for treating injury to acute soft injury.Methods:①Experimental study:To observate the effect of dimethylbenzene to the degree of rat auricle swell,and hot-plate method to the ache of rats with Anti-bruise powder for comparision.②Clinicle Study:With anti-bruise powder for comparision,to grade the painful tumefaction and dysfunction and other main sympton that are initiated by acute soft injury.Results:①The ointment has anti-inflammatory action to the acute inflammation of rat auricle swell that is made by dimethylbenzene and has easepain action for the ache made by hot-plate method.There is a marked difference compared with the control group.(P<0 05) ②There is an extramarked difference between the dinicle effective rate and that of the control group(P<0 01);In grades,the therapeutic group is better than the control group in easepain,detumescence and improving function of joint.Conclusion:Ointment NO.Ⅰ for treating injury has anti-inflammatory action and easepain action and marked clinicle curative effect for acute soft tissue injury.