骆驼奶对2型糖尿病防治作用试验研究

Preventive and Therapeutic Effects of Camel Milk on Type 2 Diabetes Mellitus

探讨骆驼奶对2型糖尿病预防和治疗作用。采用预防性灌胃骆驼奶后在造模和先造模再治疗性灌胃骆驼奶两种方法,分别与对照组、糖尿病模型组、牛奶组、盐酸二甲双胍组和驼奶与盐酸二甲双胍混合组比较,研究骆驼奶对由高脂饮食联合链脲佐菌素(Streptozotocin,STZ)诱发2型糖尿病模型小鼠的预防和治疗作用,并测定其空腹血糖(glucose)含量、血清超氧化岐化酶(superoxide dismutse,SOD)活性、谷胱甘肽过氧化物酶(glutathione peroxidase,GSH-Px)活性、丙二醛(malon dialdehyde,MDA)含量及甘油三酯(triglyceride,TG)、总胆固醇(total cholesterol,TC)、高密度脂蛋白胆固醇(high density lipoprotein cholesterol,HDL-C)、低密度脂蛋白胆固醇(low density lipoprotein,LDL-C)的含量。结果表明:骆驼奶能显著降低2型糖尿病小鼠空腹血糖,增加其血清SOD、GSH-Px活性和HDL-C含量,降低血清MDA、TG、TC、LDL-C含量。因此,骆驼奶有较好的预防和治疗2型糖尿病的作用。

In this study, two ways were used to investigate and explain the preventive and therapeutic effects of camel milk on type 2 diabetes mellitus. One way was to feed the C57BL/6 mice with camel milk and high fat diet for 35 days, then the mice were intraperitoneally injected with Streptozotocin; and in another way, C57BL/6 mice were given high fat diet for 35 days, tollowed by intraperitoneally injection with streptozotocin to establish type 2 diabetes mellitus models, and then the mice were fed with camel milk. Finally the SOD and GSH-Px activity, blood glucose level, and malon dialdehyde （MDA） , triglyceride （TG）, total cholesterol （TC）, HDL-C, LDL-C were determined in the control group, diabetes mellitus model group, milk group, metformin hydrochloride group and camel milk and metformin hydrochloride mixed group. The results showed that camel milk can significantly reduce the glucose level, MDA, TG, TC and LDL2C contents in blood, and enhance the SOD and GSH-Px activity, and HDL-C content of diabetes mellitus mice. Therefore, camel milk has preventive and therapeutic effects on hyperglycemia and hyperlipidemia, and can effectively enhance the anti-oxidation ability of type 2 diabetes mellitus mice.