复方左旋多巴制剂的研究进展

Advancement in compound levodopa

左旋多巴治疗帕金森病有40多年的历史,一直是治疗帕金森病的主要药物。但长期应用左旋多巴后,会引起"开-关"现象和运动障碍等并发症,给患者带来极大的痛苦。提高临床疗效、减少并发症的发生,延缓帕金森病进程是治疗帕金森病的重点内容。现综述近年来复方左旋多巴制剂,包括目前临床使用中的药物和制药公司研发的药物的研究进展。

Levodopa has been the main drug for the treatment of Parkinson＇s disease for more than 40 years. However, its therapy is accompanied by ＂on-off＂ phenomenon and dyskinesia, as well as other side-effects after long period treatment, which brings great suffers to the patients. How to improve the clinical efficacy, reduce the incidence of complications and slow down the process of Parkinson＇s disease are central topics in the treatment of Parkinson＇s disease. Some drugs that are widely used in clinic and under the development are included in this review.