急性脑梗死患者血浆生长抑素、P物质含量的变化及其临床意义

The Changes of Somatostatin and Substance P Levels and Their Clinical Significance in Acute Cerebral Infarction

为探讨生长抑素 (SS)、P物质 (SP)与急性脑梗死的关系 ,作者用放射免疫分析法对 60例急性脑梗死患者血浆SS、SP含量进行动态检测 ,同时检测 2 0名正常人作为对照。检测结果 :急性脑梗死患者病程第一周SS为 2 0 6.0 7± 4 3.96pg/mL ,SP为 14.0 8± 2 .56pg/mL ,第三周SS为 118.77± 2 7.87pg/mL ,SP为 19.97± 5.2 2pg/mL。与对照组第一周SS163.4 2± 10 .2 9pg/mL ,SP 2 9.62± 8.57pg/mL相比较以及组内前后比较均有统计学意义。提示SS、SP与急性脑梗死有关 ,可能参与脑梗死的发病过程。

In order to study the relationship between SS and SP in acute cerebral infarction(ACI). The levels of plasma SS and SP were observed dynamically by RIA in 60 patients with ACI and 30 healthy persons(control group). The level of SS at first week after ACI was 206.07±43.96pg/mL,the level of SP was 14.08±2.56pg/mL. SS at third week after ACI was 118.77 ±27.87pg/mL,and SP was 19.97±5.22pg/mL. The results showed the levels of SS, SP in ACI were significantly different compared with that of normal control group. The levels of SS, SP at first week after ACI werer also significantly different compared with those at third week. This concluded that SS, SP might play a role in onset and development of ACI.