紫杉醇与顺铂同步化疗联合放疗治疗老年食管癌效果评价

Clinical Research on Paclitaxel and Cisplatin Concurrent Chemotherapy Combined with Radiotherapy for Elderly Esophageal Cancer

目的：探讨紫杉醇与顺铂同步化疗联合放疗治疗老年食管癌的临床疗效。方法：随机将120例老年食管癌患者均分为对照组与观察组,对照组（n=60）采用三维适形放射治疗,总剂量为50-64Gy25-32次,6-8后完成；观察组（n=60）采用紫杉醇与顺铂同步化疗联合三维适形放射进行同期治疗。将对照组与观察组两组患者的临床疗效、近期生存质量、毒副反应以及TTP、MST比较等方面进行对比。结果：（1）对照组总有效率（PR＋CR）明显低于观察组治疗总有效率（P〈0.01）；（2）根据生存质量评估标准,对照组患者治疗后的生存质量得分为明显低于观察组患者（P〈0.01）；（3）二组出现的副反应为骨髓抑制、放射性食管炎及放射性肺炎,对照组与观察组所出现的副反应比例不存在统计学差异（P〈0.05）；（4）对照组与观察组患者随访8-48个月,对照组死亡38例人,观察组死亡36例,观察组TTP与MST均要比对照组早,其中二者在TTP上的差异具有统计学意义（P〈0.05）。结论：将紫杉醇与顺铂同步化疗联合放疗治疗的方法用于治疗老年食管癌患者,其临床效果尤佳,患者短期生存质量有所提高。

Objective： To explore clinical efficacy of the paclitaxel and cisplatin concurrent chemotherapy combined with radiotherapy in elderly esophageal. Methods：We randomly divided 120 cases of elderly patients with esophageal cancer into control group and observation group. The control group（n=60） were carried out 3-D conformal radiation therapy to a total dose of 50-64Gy25-32 after 6 to 8;and the observation group（n=60） were carried out 3-D conformal radiation therapy with paclitaxel and cisplatin synchronous chemotherapy. And compare the clinical efficacy of the two groups of patients in the control and observation groups, the recent quality of life, toxicity, and of TTP, the MST. The difference between groups demonstrates P〈0.05. Results： （1） the control group response rate （PR ＋ CR） was significantly lower than the observation group（P〈0.01）;（2） according to the quality of life assessment criteria, the score was （102＆#177;7） points of the control group after treatment, and the observation was （131＆#177;8） points. There was statistically significant learning difference between the two groups（P〈0.01）. （3）two sets of side-effects were myelosuppression, radiation esophagitis and radiation pneumonitis, control and observation groups, the proportion of side effects is not a statistical difference （P＆gt; 0.05）; （4） the control group and the observation group were followed up for 8 to 48, the control group, 38 cases of death in the observation group, 36 cases died, and the observation group TTP and MST than the control group as early as two of them the difference in TTP statistically significant （P〈0.05）. Conclusion： Paclitaxel and cisplatin with concurrent chemotherapy combined with radiotherapy for the treatment of elderly patients with esophageal carcinoma, had a prefer effect. The short-term survival of patients was improved.