摘要
58只300～350g 雄性 Wistar 大鼠,氨基甲酸乙酯腹腔麻醉,电刺激(0.5ms,80～100Hz,8～10V,40s)并以 L-谷氨酸(L-Glu)或红藻氨酸(KA)检测性验证,提示大鼠延脑腹面加压区(VSMp)位于Ⅻ对脑神经根部联线上方1.0～1.8mm,中线旁开1.2～2.0mm 的范围;电刺激 VSMp 后在升压反应的同时骨骼肌血管阻抗上升37.08%(P<0.001);肾血管阻抗上升26.5%(P<0.01).实验证明VSMp 是维持外周血管紧张性的重要来源,在动脉血压的稳态调节中起重要作用.
Experiment was performed on 58 wistar rats.The arterial pressure(AP)and the perfusion pressure of hind limb muscles and left kidney were recorded with a constant pressure device in which the changes of perfusion pressor were directly proportional to those in vascular resistance.The results showed that: (1)Electrical stimulation was used to explore the site of pressor area in ventral surface of medulla ob- longata(VSMp)and then verified with L-glutamate(L-Glu)or kainic acid(KA).The VSMp was limit- ed in following regions:1.0～1.8mm rostral to median rootlet of the Ⅻ nerve and 1.2～2.0mm later- al to medline.(2)The responses to electrical stimulation of VSMp showed a rise of AP(44.49%,P< 0.001),vascular resistance of muscles(VRm 37.08%,P<0.001)and vascular resistance of kidney (VRk 26.59,P<0.01).The results indicated that VSMp was the important area in maintaining the resting level of AP.
关键词
延脑腹加压区
动脉血压
血管阻抗
pressor area of ventral surface of medulla oblongata
arterial pressor
vascular resistance
L-glutamic acid
kainic acid
