爱普列特老年人体单次给药药代动力学研究

Pharmacokinetics of Epristeride in Old Male Volunteers

目的：进行老年人口服１０ｍｇ爱普列特的单次给药药代动力学试验。方法：用ＨＰＬＣ法测定给药后的血药浓度。结果：测定的主要药代动力学参数为：Ｃｍａｘ＝０．１８±０．０７ｍｇ·Ｌ－１；Ｔ１／２Ｂ＝５．０９±２．７３ｈ；ＡＵＣ＝１．８５±０．６９ｍｇ·ｈ·Ｌ－１；Ｖ（ｃ）／Ｆ ３８．１７±１１．１５Ｌ；Ｔｐｅａｋ＝２．９９±０．４９ｈ。结论：爱普列特在老年人体内的药代动力学特性在同剂量下与青年人的一致。

OBJECTIVE: To study the pharmacokinetics of epristeride in old healthy male volunteers. METHODS: The concentrations of epristeride in serum samples were determined by HPLC. RESULTS: The pharmacokinetic parameters obtained in the old volunteers were: Cmax=0.18±0.07mg·L-1;T1/2B=5.09±2.73h;AUC=1.85±0.69mg·h·L-1;V(c)/F 38.17 ±11.15L;Tpeak=2.99±0.49h。 CONCLUSIONS: The pharmacokinetic profile of epristeride in old man was same as in young man with same dose level.