长期应用阿替洛尔致血脂代谢异常的临床分析

Clinical analysis on effects of long term treated with atenolol for serum lipid levels

［目的］探讨长期口服阿替洛尔患者血脂水平的变化及其临床意义［方法］给５４例高血压及 冠状动脉硬化性心脏病患者连续口服阿替洛尔３个月，观察用药前后甘油三酯、总胆固醇和高密度脂蛋 白的水平［结果］阿替洛尔可使血甘油三酯升高，高密度脂蛋白降低，且随着时间的延长，差异更为明 显，总胆固醇无明显变化．［结论］长期服用阿替洛尔时应动态监测血脂水平，而不要局限于该值是否正 常，从预防与治疗动脉硬化角度来看，应选用有内源性拟交感作用的β肾上腺素能受体阻滞剂．

OBJECTIVE To study the levels of serum lipid and the clinical significance in patients long term treated with the atenolol. METHODS In 54 cases of hypertension and coronary heart disease, the levels of total cholesterol, tyiglycerides and high density lipoprotein cholesterol were detected before and after atenolol treatment for three months. RESULTS After treated with the atenolol, the levels of serum lipid were increased and of high density lipoprotein cholesterol were decreased, and there had significant difference with elapsing the time, but there had no changes in the levels of total cholesterol. CONCLUSION When the patients treated long term with the atenolol, the levels of serum lipid should be monitored, which is not limited in normal or abnormal. From the point of view for preventment and treatment of arteriosclerosis, it should be selected that the beta adrenoceptor blocking medicines that had the intrinsic sympathomimetic activity.