肝硬变患者并发胆石症的相关因素

Correlative factors of cholelithiasis with hepatocirrhosis

［目的］探讨肝硬变患者胆石症的发生率及其相关因素．［方法］分析３７４例肝硬变患者胆石症的 发生与民族、性别、年龄、肝硬变病因、肝功能Ｃｈｉｌｄ－ｐｕｓｈ分级以及肝功能生物化学指标之间的关系，并与 ３８６例非肝病对照组进行比较［结果］肝硬变患者胆石症的发生率高于对照组， ５０岁以上组高于 ４０岁以 下组，肝功能Ｂ级和Ｃ级组高于肝功能Ａ级组；肝硬变胆石症组血清总胆红素和总胆汁酸高于非胆石症 组，而血清白蛋白低于非胆石症组［结论］肝硬变患者常并发胆石症，并与年龄、肝功能障碍程度以及肝 功能损害造成的血清总胆红素、总胆汁酸和血清白蛋白代谢障碍等因素密切相关．

OBJECTIVE To study the incidence and correlative factors of cholelithiasis in the patients with hepatocirrhosis. METHODS It was analyzed that the relationship between the incidence of cholelithiasis and nationality, sex, age, cause of hepatocirrhosis, degree of liver function Child-pugh and biochemical indices of liver function in 374 patients with hepatocirrhosis, and it was compared with 386 cases of normal individuals as a control group. RESULTS The incidence of cholelithiasis with hepatocirrhosis was higher than that in control group. The incidence of cholelithiasis in over 50-year-old, the degree of liver function Child-pugh B and C were higher than that in under 40-year-old and that Child-pugh A groups, respectively. Total serum bilirubin and bile acid in hepatocirrhosis with cholelithiasis were higher than that in hepatocirrhosis without cholelithiasis and the serum albumin was lower than that in hepatocirrhosis without cholelithiasis. CONCLUSION The patients with hepatocirrhosis are commonly complicated with the cholelithiasis and it is correlated to the factors of age, degree of hypohepatia and dysbolism of total bilirubin, total bile acid and albumin induced by the hypohepatia.