摘要
研究抗生素和抗癌药对中性粒细胞(PMNL)功能的影响,发现血药浓度的庆大霉素、甲硝唑、氨甲蝶呤、三尖杉酯碱和环磷酰胺均能降低 PMNL 的吞噬和杀菌功能.当抗癌药与两种抗生素联合应用时,其抑制 PMNL 吞噬功能的作用有所增强。上述药物还能增强白色念珠菌(白念)粘附组织细胞的作用。小鼠经静脉接种白念后发生的播散性念珠菌病可因环磷酰胺处理而加重。
The effects of antibiotics and antineoplastics on PMNL function were studied.The results showed that gentamicin,metronidazole,methotrexate,harringtoninum and cyclophosphamide could inhibit phagocytic and candidacidal function of PMNL in therapeutic concentration.The effect on phagocytosis was enhanced by combination of antibiotics and antineoplastics.These Drugs also enhanced adherence of C.albicans.Additionally,candidiasis which resulted from intravascular inoculation of C.albicans in mice became more serious under cyclophosphamide treatment.
关键词
白色念珠菌
中性粒细胞
抗生素
candidiasis,polymorphonuclear,antibioties,antineoplastics
