摘要
将181例服用他巴唑(MMI)的甲亢患者分为:10mg,3/d(A);30mg 顿服(B);5mg,3/d(C);15mg 顿服(D);10mg/d(E).结果 A～D 组甲状腺功能恢复正常所需的时间分别为4.1±1.5,3.9±1.3,4.3±1.6和4.3±1.7周,无显著差异,E 组(7.8±2.1周)显著长于其他各组。67例 PD 试验表明15mgMMI 抑制碘的有机化作用与30mg 者相似,可维持24h。C,D 组(14.9%)与 E 组(5.6%)不良反应明显少于 A,B 组(38.2%)。以上结果提示15mg/dMMI 是治疗甲亢理想剂量,每日一次顿服的疗法合理有效。
181 patients with hyperthyroidism were at random divided into 5 groups:group A 10mg methimazole(MMI),3 times daily;group B 30mg MMI once daily;grorp C 5mg,3 times daily;group D 15mg once daily;group E 10mg daily.The mean time to achieve euthyroidism was not significantly different among group A,B,C and D,and was 4.1±1.5,3.9±1.3,4.3±1.6 and 4.3±1.7 weeks, respectively,but in group E(7.8±2.1 weeks)it was apparantly longer than that in group A,B,C and D.The results of perchlorate discharge test in 67 MMI—untreated patients demonstrated that the inhibitory effect of 15mg MMI on iodide organification was similar to that of 30mg MMI and might maintain for 24h.The rate of side—effects in patients treated with 15mg daily(14.9%),10mg daily (5.6%)was considerably less than that in patients treated with 30mg daily(38.2%).Our data indicate that small dose of 15mg MMI daily is optimal dose for treating hyperthyroidism,and the therapy of small single daily dose of 15mg MMI is reasonable and effective for treatment of hyperthyroidism.
关键词
甲亢
他巴唑
疗效
hyperthyroidism
methimazole
perchlorate discharge test
