利培酮药物治疗对首发精神分裂症患者血清β2-微球蛋白及超敏C反应蛋白水平的影响

Risperidone drug treatment Effect On Serum Beta 2-microglobulin And High-sensitivity C-reactive Protein Level in First-episode Schizophrenia Patients

目的：探讨首发精神分裂症患者服用利培酮对血清β2-微球蛋白及超敏C反应蛋白的影响。方法：对60例单服用利培酮治疗的首发精神分裂症患者进行治疗前、治疗后4周、治疗后8周的血清β2-微球蛋白及超敏C反应蛋白检测分析，并与60名健康者（对照组）进行比较。结果：精神分裂症患者服用利培酮药物在治疗前与治疗后8周的血清β2-微球蛋白分析对比有统计学差异（P〈0．05）；血清超敏c反应蛋白水平在治疗前及治疗后4周的分析对比，有统计学差异（P〈0．05）；血清超敏C反应蛋白水平在治疗前与治疗后8周分析对比，有统计学显著差异（P〈0．01）。结论：长时间服用抗精神病药利培酮可导致精神分裂症患者血清β2-微球蛋白及超敏C反应蛋白代谢异常。

Objective ： To investigate how taking risperidone by first-episode schizophrenia patients affects sermn beta 2-microglobulin and high-sensitivity C-reactive protein. Methods ： test and analyze serum beta 2-microglobulm and high sensitivity C-reactive protein of 60 cases of risperidone treatment on first-episode schizophrenic patients before treamlent, 4 weeks after treatment and 8 weeks after treatment and 60 healthy subjects （control group） were compared.Results ： analyze and compare serum beta 2-microglobulin from the patients with schizophrenia who took risperidone before before treatment and 8 weeks after treatment and find significantly statistical difference （P 〈0.05）; analyze and compare serum high-sensitivity C-reactive protein level and find significantly statistical difference （P 〈0.05）; analyze and compare serum high sensitivity C-reactive protein levels and find significantly statistical differences （P 〈0.01）. Conclusions ： taking the antipsychotics risperidone for a long time can bring schizophrenia patients metabolic abnormalities of serum beta 2-microglobulin and high-sensitivity C-reactive protein.