甲状腺功能亢进症^(131)I治疗后甲状腺功能低下的原因分析

Cause analysis of hypothyroidism after ^(131)I treatment for hyperthyroidism

目的分析甲状腺功能亢进症131I治疗后甲状腺功能低下的原因,探讨其控制对策。方法回顾性分析天门市第一人民医院内科2010年7月~2013年4月收治的500例甲状腺功能亢进症患者的临床资料。结果 >50~75岁的患者、甲状腺重量在80 g以上的患者、甲亢重度患者、无突眼患者、服131I剂量为222~333 MBq的患者、服131I 1次的患者甲状腺功能低下发生率均较高,和其他患者比较,差异有统计学意义(P<0.05)。结论甲状腺功能亢进症131I治疗后甲状腺功能低下的原因主要是患者的年龄大、甲状腺大、甲亢重度、无突眼、服131I剂量控制不良、次数过少等,临床应采取有针对性的措施予以控制。

Objective To analyze the causes of hypothyroidism after 131I treatment for hyperthyroidism and explore its coun- termeasures. Methods The clinical data of 500 patients with hyperthyroidism hospitalized in the Department of Internal Medicine from the First People＇s Hospital of Tianmen City from July 2010 to April 2013 were analyzed retrospectiveiy. Resuits Compared with other patients, the ones between 〉50-75 years of age, the ones with thyroids weighing 80 g above, the ones with severe hyperthyroidism, the ones with no exophthalmos, the ones taking 131I with a dosage between 222-333 MBq, and the ones who took 131I only once had higher rates of being affected by hypothyroidism, which showed statistically significant differences （P 〈 0.05）. Conclusion The main causes of hypothyroidism after 131I treatment for hyperthyroidism are old ages of patients, big thyroids, severe hyperthyroidism, no exophthalmos, improper control of 131I intake, few times of intake and other causes. Targeted countermeasures should be applied clinically to control the situation.