头孢曲松钠他唑巴坦钠治疗血清固定梅毒的效果观察

Effect observation of ceftriaxone sodium/tazobactam sodium in the treatment of serofast syphilis

目的观察头孢曲松钠他唑巴坦钠治疗血清固定梅毒的临床效果。方法选取2010年6月～2012年12月本院收治的血清固定梅毒患者44例为研究对象，采用随机分组的方法分为观察组和对照组。观察组22例，给予头孢曲松钠他唑巴坦钠治疗；对照组22例，给予苄星青霉素治疗。治疗3、6个月比较两组患者的效果。结果治疗3个月后．观察组患者总有效率为68．2％，明显高于对照组的40．9％，差异有统计学意义（P〈0．05）。治疗6个月后，观察组患者总有效率为81．8％，明显高于对照组的54．5％，差异有统计学意义（P〈0．05）。结论头孢曲松钠他唑巴坦钠治疗血清固定梅毒较苄星青霉素可明显提高治疗效果，有效降低早期梅毒快速血浆反应素环状卡片试验滴度，值得临床推广应用。

Objective To observe the therapeutic effects of ceftriaxone sodium/tazobactam sodium in the treatment of serofast syphilis.Methods 44 patients with serofast syphilis in our hospital from June 2010 to December 2012 were selected as research objects and randomly divided into observation group and control group.22 patients of observation group were treated with ceftriaxone sodium/tazobactam sodium,22 patients of control group were treated with benzathine benzylpenicillin.The therapeutic effects of two groups after 3 and 6 months of treatment were compared.Results After 3 months of treatment,total effective rate of observation group was 68.2%,significantly higher than that of control group （40.9%）,with a statistical difference （P〈0.05）.After 6 months of treatment,total effective rate of observation group was 81.8%,significantly higher than that of control group（54.5%）,with a statistical difference（P〈0.05）.Conclusion Ceftriaxone sodium/tazobactam sodium in the treatment of serofast syphilis than benzathine benzylpenicillin can significantly improve the therapeutic effect,reduce early syphilis rapid plasma reagin test titre,is worthy of clinical application.