肿瘤光动力治疗临床应用的光敏剂及其研究概况

Photosensitizer Used in Clinical Photodynamic Thearpy for Cancer

光动力治疗是一种非侵蚀性并具有一定靶向性的肿瘤治疗新方法。光动力治疗需要光敏剂、光和氧结合产生光动力反应。光敏剂是光动力治疗的关键和物质基础。本文概括介绍了已上市的和已被批准进入临床试验中的光敏剂,并根据其分子的骨架结构,将其分为分卟啉类、二氢卟吩(叶绿素)类和菌绿素/酞菁三类。同时从理想光敏剂应具备特点出发,探讨了研究中的光敏剂和光动力治疗的发展前景。

Photodynamic therapy （PDT） has emerged as a selective and non-invasive modality for the treatment of malignant tumors. Photosensitizers are the key component of PDT, which generates cytotoxic reactive oxygen species （ practice, three families of ROS） in the presence of oxygen and light with appropriate wavelength. In clinical photosensitizer（tX3） are used, including porphyrins, chlorophylls and bacteriochloyin/ phthalocyanines. This review focused on the oncologic photosensilizers that were in clinical uses or trials and from the points of view of successful photosensitizers explored the future trends of PS and PDT.