期刊文献+

叶酸的母胎保护作用 被引量:6

原文传递
导出
摘要 叶酸属B族维生素,是DNA和RNA合成过程中所需的重要物质,为一碳代谢的重要甲基供体。叶酸参与体内所有的生化代谢过程,参与人体内许多重要物质如蛋白质、脱氧核糖核酸、血红蛋白的合成及磷脂代调十,在细胞生长、分化、修复和宿主防御等方面起着重要作用。国内外学者对其在生殖领域的作用进行了大量的研究,
作者 张蔼 段涛
出处 《中国实用妇科与产科杂志》 CAS CSCD 北大核心 2013年第12期993-995,共3页 Chinese Journal of Practical Gynecology and Obstetrics
基金 上海卫生新百人计划(No:XBR2011064)
关键词 叶酸 先天性畸形 妊娠相关疾病 folic acid congenital abnormalities pregnancy-related diseases
  • 相关文献

参考文献18

  • 1FoxJT, Stover PJ. Folate-mediated one-carbon metabolism[J]. Vitam Horm ,2008,79: 1-44.
  • 2Den Heijer M, Lewington S, Clarke R. Homocysteine, MTHFR and risk of venous thrombosis: a meta-analysis of published epi?demiological studies[J].J Thromb Haemost, 2005 ,3 (2) : 292- 299.
  • 3Yuan Q, Zhao S, Liu S, et al. Folic acid supplementation chan?ges the fate of neural progenitors in mouse embryos of hypergly?cemic and diabetic pregnancy[J].J Nutr Biochem, 2013 , 24 (7) :1202-1212.
  • 4van Beynum 1M, Kapusta L, Bakker MK, et al. Protective effect of peri conceptional folic acid supplements on the risk of congenital heart defects: a registry-based case-control study in the northern Netherlands[J]. Eur HeartJ,201O,31 (4) :464- 471.
  • 5Li X, Li S, Mu 0, et a1. The association between periconcep?tional folic acid supplementation and congenital heart defects: A case-control study in China[J]. Prev Med,2013,56(6) :385- 389.
  • 6Smoak IW. Hypoglycemia and embryonic heart development[J]. Front Biosci,2002,7 :d307-d318.
  • 7Ohara Y,Atarashi T, Ishibashi T, eta1. GATA-4 geneorganiza?tion and analysis of its promoter[J]. BioI Pharm Bull, 2006,29 (3) :410-419.
  • 8Fodor E, Ginshurg A. Specific DNA hinding by the home?odomain Nkx2. 5 ( C56S) : detection of impaired DNA or unfol?ded protein by isothermal titration calorimetry[J]. Proteins, 2006,64(1) :13-18.
  • 9Yang HT, Lee M, Hong KS, et al. Efficacy offolic acid supple?mentation in cardiovascular disease prevention: An updated me?ta-analysis of randomized controlled trials[J]. EurJ Intern Med,2012 ,23 (8) :745-754.
  • 10Kelly 0, 01>owd T, Reulbach U. Use of folic acid supple?ments and risk of cleft lip and palate in infants: a population?based cohort study[J]. BrJ Gen Pract,2012,62(600) :e466- e472.

同被引文献53

引证文献6

二级引证文献35

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部