高龄五指山小型猪近交系血液生化指标测定

Blood Biochemical Tests of Senior Inbred Wuzhishan Miniature Pigs

目的了解猪龄和性别对五指山小型猪(WZSP)近交系血液生化指标的影响。方法 WZSP近交系F17、F186月龄青年猪34头(7♂,27♀),5—6高龄猪21头(8♂,13♀),禁食12 h后经由前腔静脉采血,用全自动生化分析仪检测血液生化指标。结果青年猪和高龄猪有部分血液生化指标具有性别差异(P<0.05),其中青年猪有3项高龄猪有7项;青年猪和高龄猪有16项血清生化指标具有差异(P<0.05)。结论 WZSP近交系血液生化指标有着明显的年龄差异,这对选用高龄猪作为人类老年化动物模型提供了基础参考数据。

Objective To analysis the blood biochemical parameters influenced by age and gender of inbreed Wuzhishan miniature pigs.Method 34 6-month-old pigs （7 ♂,27 ♀）,as well as 21 pigs of 5-6 years old（8 ♂,13 ♀）from F17,F18 offsprings of inbred WZSP were selected.After 12 hours of fasting,blood was collected via the superior vena cava and biochemical indexes were analyzed by full-Automatic biochemical analyzer.Result In all the blood biochemical indexes,3 of them showed gender differences （P ＜ 0.05） between young pigs,while 7 of them showed gender differences （P ＜ 0.05） among aged pigs.Meanwhile 16 of the blood biochemical indexes showed age differences （P ＜ 0.05）.Conclusion The blood biochemical indexes of WZSP inbred lines display a significant age difference （P ＜ 0.05）.This provides a basic reference data for choosing the aged miniature pigs as human aging animal models.