FoxM1、c-myc蛋白在基底细胞样型乳腺癌中的表达及其临床意义

Clinical significance of protein expressions of FoxM1 and c-myc in basal-like breast cancer

目的 探讨FoxM1和c-myc蛋白在基底细胞样型乳腺癌（BLBC）、非基底细胞样型乳腺癌（non-BLBC）及癌旁正常乳腺组织中的表达情况及二者之间的相互关系.方法 采用免疫组织化学法检测66例BLBC及其癌旁正常乳腺组织、70例non-BLBC组织FoxM1和c-myc蛋白的表达情况,采用Spearman相关分析法分析其与病理临床特征的关系.结果 BLBC、non-BLBC及癌旁正常乳腺组织中FoxM1蛋白阳性表达率分别为77.3％（51/66）、60.0％（42/70）和13.6％（9/66）,c-myc蛋白阳性表达率分别为71.2％（47/66）、54.3％（38/70）和22.7％（15/66）,FoxM1和c-myc蛋白在BLBC和non-BLBC组织中表达率均明显高于癌旁正常乳腺组织,且在BLBC组织中的表达明显高于non-BLBC组织,差异均有统计学意义（均P＜ 0.05）.在BLBC中FoxM1和c-myc蛋白表达呈正相关（r=0.294,P＜ 0.05）,且FoxM1和c-myc蛋白的表达与BLBC淋巴结转移及临床分期有关（P＜0.05）.结论 FoxM1和c-myc蛋白参与了BLBC的发生、发展,并且FoxM1和c-myc蛋白有一定的协同作用.

Objective To detect the protein expressions of FoxM1 and c-myc in basal-like breast carcinoma and explore their correlation.Methods The expression of FoxM1 and c-myc was detected in 66 cases of BLBC,70 cases of non-BLBC and 66 cases of normal adjacent breast tissue by immunohistochemistry.The relationship of them was analyzed.Rusults The expression rates of FoxM1 and c-myc protein in BLBC [77.3 % （51/66）,71.2 % （47/66）] was significant increased than that in normal breast tissue [13.6 % （9/66）,22.7 % （15/66）],and higher than that in non-BLBC [60.0 % （42/70）,54.3 % （38/70）].The expression of FoxM1 and c-myc positively correlated with lymph nodes metastasis and TNM staging of BLBC （P 〈 0.05）.Positive expressions correlation could be found between the expression of FoxM1 and that of c-myc as well （r =0.294,P 〈 0.05）.Conclusion FoxM1 and c-myc may play important roles in the carcinogenesis and development of BLBC and the study supports the positive feedback effect between the expressions of FoxM1 and c-myc furthermore.