酮咯酸氨丁三醇在预防鼻窦手术术后疼痛中的应用

The Application of Ketorolac Tromethamine on Postoperative Pain in Patients Following Endoscopic Sinus Surgery

目的:探讨酮咯酸氨丁三醇对鼻内镜下鼻窦手术术后早期疼痛的预防效果及安全性。方法:取60例择期行鼻内镜下鼻窦手术成年患者,随机分为酮咯酸组和芬太尼组,均采取全凭静脉麻醉,于雷米芬太尼停止泵入前15min分别静脉予以酮咯酸氨丁三醇30mg或芬太尼50μg,观察术后疼痛及出血情况。结果:两组患者术后疼痛(30min 3.2±1.3vs 3.4±1.5,60min 2.0±1.1vs2.8±2)及出血情况(鼻出血VAS评分6.6±3.1VS 5.1±3.1,痰中带血VAS评分3.1±1.8vs 3.4±1.8,更换敷料VAS评分5.2±3.5vs 4.3±3.4)差异均无统计学意义。结论:手术结束前静脉给予酮咯酸氨丁三醇可以较好的替代麻醉性镇痛药用于预防鼻内镜下鼻窦手术的成年患者术后镇痛而不增加术后出血风险。

Objective： To observe the effects and safety of ketorolac tromethamine on postoperative pain management in patients following endoscopic sinus surgery （ESS）. Methods： Sixty patients underwent ESS , under total intravenous anesthesia, randomly received either ketorolac tromethamine 30 mg or fentanyl 50μg 15 rain before remifentanil infusion stopped. Then the pain and bleeding VAS score were recorded. Results： No significant differences were found in pain score and bleeding measurement between the two groups. Con- clusions ： In this study, ketorolac tromethamine was a safe analgesic on postoperative pain following ESS in a- dults, with similar effects of pain relief of fentanyl, and with no increased risk of postoperative bleeding.