NSFC funded researchers achieved major breakthroughs in acetylation-mediated degradation of core histones

Acetylation is a major type of protein posttranslational modification,and is found in more than 7,000 human proteins(FEES Lett 2012,586:2692).It regulates many critical cellular activities,such as epigenetic regulation of gene expression,DNA repair,and spermatogenesis.However,the mechanism by which acetylation regulates these critical processes remains unclear.Proteasomes catalyze ATP-and polyubiquitin-dependent degradation of most cellular proteins(Physiol Rev 2002,82:373;Nature2003,426:895).However,the ubiquitin enzymes,which catalyze the polyubiquitin-mediated degradation of histones,have not yet been i-

Acetylation is a major type of protein post- translational modification, and is found in more than 7,000 human proteins （FEBS Lett 2012, 586： 2692）. It regulates many critical cellular activities, such as epigenetic regulation of gene expression, DNA repair, and spermatogenesis.