“硅替代”新药创制研究进展

Progress on the “Silicon Substitution” of Drugs

"硅替代"新药创制即合成现有药物的含硅结构类似物.含硅药物与其碳结构类似物相比,具有独特的理化性质,并表现出特定的生物活性,如更强的药效、更高的选择性和更小的毒副作用.因此,对现有药物进行硅替代是设计、改造药物的有效途径.文章对各种硅替代药物进行了全面综述.

＂Silicon substitution＂ of drugs, is to synthesize silicon-containing analogs of the known drugs. Compared with the all-carbon counterparts, silicon-containing drugs have specific features, such as better curative effects, higher selectivity, less toxicity and side effects. Silicon substitution of drugs is a practical approach for drug design and innovation. This paper reviewed all kinds of silicon substitution of drugs.