摘要
"硅替代"新药创制即合成现有药物的含硅结构类似物.含硅药物与其碳结构类似物相比,具有独特的理化性质,并表现出特定的生物活性,如更强的药效、更高的选择性和更小的毒副作用.因此,对现有药物进行硅替代是设计、改造药物的有效途径.文章对各种硅替代药物进行了全面综述.
"Silicon substitution" of drugs, is to synthesize silicon-containing analogs of the known drugs. Compared with the all-carbon counterparts, silicon-containing drugs have specific features, such as better curative effects, higher selectivity, less toxicity and side effects. Silicon substitution of drugs is a practical approach for drug design and innovation. This paper reviewed all kinds of silicon substitution of drugs.
出处
《杭州师范大学学报(自然科学版)》
CAS
2013年第6期555-561,共7页
Journal of Hangzhou Normal University(Natural Science Edition)
基金
国家自然科学基金项目(21006018)
杭州市科技局项目(20092113A03
20101131N03)
关键词
硅替代
含硅药物
药物设计
silicon substitution
silicon-containing drug
drug design