冠状动脉造影数字跟踪技术测定心脏X综合征患者冠状动脉血流储备的临床观察

Clinical observation of coronary flow reserve in patients with cardiac syndrome X by tracking digital angiography

目的通过常规冠状动脉造影,运用数字跟踪技术软件测定心脏X综合征患者冠状动脉血流储备(coronary flow reserve,CFR),探讨其变化意义。方法 98例拟诊冠状动脉粥样硬化性心脏病(冠心病)患者,其中心脏X综合征患者62例,对照组36例。冠状动脉造影同时运用数字跟踪技术软件测算CFR,抽血检测血清高敏C反应蛋白(high-sensitivity C-reactive protein,hsCRP)浓度,利用统计软件比较两组检测结果。结果 X综合征组患者CFR低于对照组,差异有统计学意义(P<0.05);血清hsCRP浓度高于对照组,差异有统计学意义(P<0.01)。结论 X综合征患者存在CFR降低及血清hsCRP浓度升高,提示CFR降低及炎症反应可能是其临床症状的病理生理基础。

Objectives To investigate and evaluate the change of coronary flow reserve （CFR） in patients with cardiac syndrome X by tracking digital angiography. Methods Ninty-eight cases with suspected coronary artery disease underwent coronary angiography. Of them, CFR of 62 cases with cardiac syndrome X and 36 matched healthy subjects were measured by tracking digital angiography, and serum concentrations of high-sensitivity C-reactive protein （hsCRP） were detected. The change of CFR and hsCRP were observed and analyzed between the two groups. Results CFR in group of cardiac syndrome X was significantly lower than that of match group （P〈0.05）, while hsCRP was significantly higher （P〈O.01）. Conclusions CFR in cardiac syndrome X group is lower than that of healthy subjects, while hsCRP is higher. This indicates that lower flow reserve and inflammation can play a key role in the pathophysiological mechanism for patients with cardiac syndrome X.