高热性惊厥患儿淋巴细胞HSP72表达水平的变化

Changes of the expression of HSP72 lymphocytes in the patients with febrile convulsion

目的观察热休克蛋白在儿童高热性惊厥中的作用。方法研究对象为22名男孩和8名女孩，均为高热性惊厥患儿，同时征集30名年龄相当的健康儿童作为对照。在发病治疗前和治疗后分别分离两组儿童的淋巴细胞并检测热休克蛋白72（HSP72）的表达。结果两组HSP72的表达均有提高，但组间比较差异无统计学意义。另外，两组对产生热休克的易感性比较差异无统计学意义。但高热性惊厥组患儿HSP72的磷酸化水平显著降低。结论热休克蛋白的翻译后修饰（磷酸化）可能参与高热性惊厥的发生。

Objective To observe the role of heating proteins in children with febrile convulsion. Methods The subjects were 22 boys and 8 girls with febrile convulsion, at the same time, 30 age - matched healthy children were collected as control. The two groups of children were evaluated, and the expressions of lymphocyte biosynthesis protein 72 in heating before and after treatment were examined. Results The cases in two groups expressed heat shock protein （HSP72） at the same time, but there was no statistically significant difference between groups. In addition, there was no significant differences in susceptibility for heated. But phosphorylation of HSP72 of the febrile convulsion cases was significantly lower. Conclusion The results suggest that the heating protein post - translational modifications （phosphorylation） may be involved in the occurrence of febrile convulsion.