血清超敏C-反应蛋白与胱抑素C检测对2型糖尿病肾病的检测意义

The Value of Detecting Serum Highsensitivity C-reactive Protein and Cystatin C levels in Type 2 Diabetic Nephropathy

目的检测并比较2型糖尿病(T2DM)及T2DM伴有糖尿病肾病(DN)患者血清超敏C-反应蛋白(CRP)及胱抑素C(Cysc)的水平变化,探讨联合检测对DN诊断的意义。方法依据24h尿蛋白的定量将90例T2DM患者分为3组,每组30例。A组:正常糖尿病肾病组(尿微量白蛋白定量UmALB<30mg/24h);B组:早期糖尿病肾病组(尿微量白蛋白定量UmALB≥30mg^300mg/24h);C组:临床糖尿病肾病(DN)组(尿微量白蛋白定量UmALB>300mg/24h);健康体检的(NC组)正常人对照组30例,分别计算各组的血清hs-CRP、CysC均值,并进行统计学分析。结果 A、B、C组血清hs-CRP及CysC水平均高于对照组,差异有统计学意义(P<0.05);B、C组血清hs-CRP及CysC水平均高于A组,差异有统计学意义(P<0.05),C组血清hs-CRP及CysC水平均高于B组,差异有统计学意义(P<0.05)。结论血清hs-CRP与CysC检测对2型糖尿病肾病早期诊断及病情监测具有重要的临床价值。

Objective To detect and compare the changes of serum high-sensitivity C-reactive protein（hs-CRP） and cystatin C（Cys C） levels in type 2 diabetes（T2DM）and with diabetic nephropathy（DN）,and to investgate the significance of combined in diagnosing DN.Methods According to 24h urinary albumin 90 patients with T2DM were divided into three groups.Every group had 30 patienrs.A group,natural diabetic group（urinary albumin,UmALB30mg/24h）30cases;B group,early diabetic nephropathy[UmALB≥（30~300）mg/24h] 30 cases;C group,clinical diabetic nephropathy（UmALB300mg/24h）30 cases;health examination groups 30 cases.Result A,B,C group serum hs-CRP and CysC levels were higher than control group, the difference was statistically significant（P〈0.05）B,C group serum hs-CRP and CysC levels were higher than A group,the difference was statistically significant（P〈0.05）.C group serum hs-CRP and CysC levels were higher than A,B group,the difference was statistically significant（P〈0.05）.Conclusion Serum hs-CRP and CysC levels detection for early diagnosis of type 2diabetic nephropathy and condition detection had important clinical value.