应用不同β-受体阻滞剂后青光眼眼动脉血流动力学分析

Assessment of ophthalmic arterial blood flow in glaucomatous eyes treated with beta blockers

目的 :观察应用不同 β -受体阻滞剂后青光眼眼动脉血流动力学变化。方法 :用彩色多普勒检测 2 0例中、晚期开角型青光眼患者 ,应用选择性β1-受体阻滞剂 0 2 5%Betaxolol和非选择性 β-受体阻滞剂 0 5%Timolol,观察治疗前和治疗 2周后眼动脉收缩期峰值血流速度 (PSV)和舒张末期血流速度(EDV)。结果 :只有 0 2 5%Betaxolol治疗组眼动脉舒张末期血流速度 (EDV)治疗前后差异有显著性 (P<0 0 5) ,0 5%Timolol治疗组EDV治疗前后差异无显著性 (P >0 0 5)。结论 :选择性 β1-受体阻滞剂增加EDV ,降低眼动脉舒张期阻力 ,保证了血流灌注。

HT5”SS][WT5”BZ][ST5”BZ]Objective:To investigate the changes of arterial blood flow in primary open angle glaucomatous eyes after treatment with different beta blockers.Methods:20 POAG patients were randomly divided into 2 groups (each group 10 patients) and selective beta blocker,0 25% Betaxolol and non selective beta blockers,0 5% Timolol were applied separately to each group (Betaxolol and Timolol groups).Color doppler ultrasound was used to measure the peak systolic velocity (PSV) and end diastolic velocity (EDV) of arterial blood flow in subjects studied,before and after treatment with beta blockers.Results:In Betaxolol group,there was significant difference (P<0 05) in the end diastolic velocity (EDV) of ophthalmic arterial blood flow between pre treatment and treatment after two weeks,but no significant difference (P>0 05) in Timolol group.Conclusion:The selective beta blockers,0 25%Betaxolol can increase EDV and decrease the vascular resistance in the diastolic phase of ophthalmic artery to the eye,thus improve the blood flow in ophthalmic artery. [HT5”H][WT5”HZ][ST5”HZ]