摘要
[目的]探讨腔内化疗配合全身化疗治疗晚期胃肠道恶性肿瘤的临床疗效。[方法]将术后腹腔转移或失去手术时机的晚期胃肠道癌随机分为治疗组和对照组。治疗组亚叶酸钙(CF)、呋喃氟尿嘧啶(FT 207)、顺铂(PDD)联用 ,行腹腔联合静脉化疗 ,对照组行CF、FT 207、PDD联用单纯静脉化疗 ,两组化疗药物总剂量相同。[结果]治疗组有效率为66.67 % ,1年生存率为60 % ;对照组有效率为40.54% ,1年生存率为35 % ,统计学差异明显(P<0.05) ,而治疗组不良反应明显轻于对照组(P<0.01)。[结论]LFP方案腹腔联合静脉化疗是治疗晚期胃肠道恶性肿瘤的有效方法 ,较单纯静脉化疗毒副作用明显减轻 ,有效率及1年生存率有所提高。
To assess the efficacy and toxicity of intraperitoneal chemotherapy combined with intravenous chemotherapy with LFP regimen in advanced gastrointestinal cancer patient.Eighty patients were randomizedly divided into two groups.The therapeutic group were treated by intraperitoneal combined with intravenous chemotherapy and the control group by intravenous chemotherapy alone.The overall dose of Leucovorin(CF), Ftorafur(FT-207) and Cisplatin(PDD) was the same in the two groups.Seventy-six patients were evaluable for efficacy.The response rate was 66.67% in the therapeutic group and 40.54% in the control group (P<0.05).The toxicity in the therapeutic group was significantly less than that in control group (P<0.01).[Conclusion]The treatment of intraperitoneal combined with intravenous chemotherapy with LFP regimen in advanced gastrointestinal patient is safe and effective.
关键词
腹腔化疗
静脉化疗
胃肠肿瘤
治疗
顺铂
intraperitoneal chemotherapy
intravenous chemotherapy
gastrointestinal neoplasms
leucovorin
ftorafur
cisplatin
