糖尿病性阴茎勃起功能障碍动物模型血清雄激素测定

Examination to testosterone in sera of erectile dysfunction rats with diabetes mellitus

SD大鼠注射链脲佐菌素制造糖尿病 (DM)动物模型后 ,注射阿朴吗啡观察不同时期大鼠阴茎勃起情况 ,筛选DM性阴茎勃起功能障碍 (ED)大鼠模型 ,测定其血清LH、FSH及睾酮的浓度 ,并观察睾丸组织的显微结构 ,研究DM性ED的发病机理。结果DM性ED大鼠血清睾酮浓度显著降低 ,睾丸组织显微结构发生明显病理性改变 ,且上述变化与DM病程密切相关 ;LH在DM早期无改变、晚期明显降低 ;FSH无明显改变。提示DM严重影响阴茎勃起功能及雄激素的合成分泌 。

To research the mechanisms of erectile dysfunction(ED) with diabetes mellitus (DM),streptozotocin(STZ) was injected intraperitoneally into Sprague Dewley rats to make experimental models of DM.Injected with apomorphine,penile erections were observed and noted on the 6th week,8th week and 12th week from the 4th day of injecting STZ and experimental models of ED with DM were selected.The concentration of LH,FSH and testosterone were examined and the microstructrure of testes were observed.The concentration of testosterone decreased significantly and the sigificant pathological changes much related to the duration of DM were observed in ED rats with DM.The concentration of LH did not change in the early duration of DM,but decreased significantly in the late duration of DM.No changes of the concentration of FSH were observed.The results indicated the function of penile erection and the synthesis of testosterone were affected seriously by DM,and the decreasing of the concentration of testosterone may be one of the most important mechanisms.