急性重复缺氧TNF-α和IL-6的变化

CHANGES OF TNF-α AND IL-6 UNDER ACUTE REPETITION HYPOXIA

目的 :探讨急性高原重复缺氧外周血肿瘤坏死因子 (TNF -α)和白细胞介素 6(IL -6)的变化 ;方法 :随机抽取某汽车部队驾驶员 1 6名 ,在开运前 1 0天 (海拔 1 40 0m)、完成 4次高原 (海拔 3 70 0m～ 5 40 0m)运输任务中途 (海拔 3 70 0m处 )及运输任务结束 (完成 8次高原运输任务 )后一个月 (海拔 1 40 0m) ,分别进行TNF -α、IL -6的检测 ;结果 :运输前及运输后较运输中途TNF -α、IL -6差异有高度显著性 (P <0 .0 0 1 ) ,运输前较运输结束后差异非常显著 ,TNF -α(P <0 .0 0 1 ) ,IL -6(P <0 .0 1 ) ;结论 :TNF -α和IL -6作为多功能细胞因子参与了低氧应激和缺氧适应过程 ,急性重复缺氧机体产生了间歇性的低氧适应。

Objective:To explore the changes of TNF-α and IL-6 under acute repetition hypoxia; Me thods :16 motor-soldiers were randomly selected and determined on TNF-α and IL-6 before they taken transport task,and middle-transporting and after 1 month task.Results:The decrease of TNF-α and IL-6 were more notable (P<0.001) before and after-transport compared with middle-transport,and there was a notably difference between before and after transportion (P< 0.01 or P< 0.001 ).Conclusion:As a mutifunction cell factor,TNF-α and IL-6 had participated hypoxia stress and hypoxia adaptation,under condition of acute repetition hypoxia,the healthy body could have the intermittent hypoxia adaptation.