快速低氧致世居藏族红细胞促粒细胞吞噬作用改变

CHANGES OF ERPN IN NATIVE TIBETAN ACUTIVE EXPOSED HIGH ALTITUDE

目的 :探讨世居藏族对快速低氧的适应机制 ,观察长期移居低海拔地区的世居藏族乘飞机进入海拔 3 60 0m高原后ERPN、WBC的变化 ,及同海拔移居适应者和世居者的上述指标 ;方法 :ERPN采用花环法 ,WBC采用常规法 ;结果 :观察组进入高原后最初 3天ERPN均升高 (P <0 .0 5和P <0 .0 1 ) ,第 2天升高尤为明显 ,较平原值升高 3 0 % ;第 7天下降接近平原值和移、世居两组P >0 .0 5 ) ;进入高原前后WBC变化不明显 ,与平原值和移、世居两组接近 (P >0 .0 5 ) ;结论 :世居藏族快速进入高原后极少发生急性高原病 ,红细胞促粒细胞吞噬作用的增强起着一定的作用 ,对低氧的适应机制与细胞水平的早期适应有关。

Objective:To explore the effects of acutive hypoxia on native Tibetan.Method:36 healthy tibetan student (aged 18～23 yr),who to be born at altitude and have been lived in lowland for 2～4 yr,were collected to exame the changes of ERPN by Rosette test after 1,2,3,7,15 and 30 days exposed high altitude and compared the results with control.Result:The level of ERPN were increased (P<0.05 or 0.01 ) in primary 3 day but decreased after the 7th day.Comclusion:The native healthy Tibetan have a few mountain sickness when they expose acutively to high altitude.We consider that the results asociate with the higher level of ERPN early.