114例药品不良反应报告分析

Adverse Drug Reaction Reports: Analysis of 114 Cases

目的:了解药品不良反应(ADR)的特点及一般规律,以促进合理用药。方法:收集2010—2011年江门市第三人民医院上报的114例ADR报告,分别从患者性别、年龄、给药途径、引发ADR的药品种类、累及器官和(或)系统及临床表现等方面进行统计、分析。结果:114例ADR报告中,70岁以上的老年患者ADR发生率最高(25例,占21.9%);引发ADR的主要给药途径为口服(99例,占86.8%);引发ADR的药物中,中枢神经系统用药居首位(83例,占72.8%);ADR累及器官和(或)系统最常见的是皮肤系统损害、消化系统损害和神经系统损害。结论:应重视ADR的监测工作,确保患者用药的安全性。

OBJECTIVE： To investigate the characteristics and regularity occurred in our hospital to promote rational use of drug. METHODS： 114 ADR of adverse drug reactions （ADR） case reports collected from 2010 to 2011 in Jiangmen Municipal Third People＇s Hospital were analyzed statistically in respect of the patients＇ sex and age, route of administration, the type of ADR-involved drugs, ADR-involved organs and （or） systems and clinical manifestations. RESULTS： Among the 114 cases, the patients aged above 70 years had the highest proportion with 25 cases （21.9%）; the ADRs were mostly induced via oral administration [99 cases （86. 8% ）]. Of the ADR- involved drugs, the drugs for central nervous system took the lead [83 cases （72. 8% ）]. The most common clinical manifestations of the ADRs were lesions of skin system, digestive system and nervous system. CONCLUSION： It is important to attach great importance to ADR monitoring to ensure patients＇ medication safety.