摘要
Objective: The aim of this study was to discuss HIF-1α expression and vasculogenic mimicry(VM) in hepatocellular carcinoma(HCC) and their relationship with the clinical pathological features and clinical significance. Methods: Two hundred and seven specimens from patients in The Affiliated Hospital of North Sichuan Medical College who received hepatic cell carcinoma resection were tested by immunohistochemistry and double staining of CD31 and PSA. Then detected the expression of HIF-1α, VM, and analysed the relationship between clinical pathology. Results: The HIF-1α positive rate was 71.01% and its expression was associated with liver cirrhosis, tumor size and TNM stage(P < 0.05). HIF-1α protein expression was positively associated with the VM(γ = 0.1988, P = 0.0041). Conclusion: Hypoxia may be the reason for VM in high invasive HCC, regulating the tumor microenvironment may have great significance in inhibiting invasion and metastasis of HCC.
Objective： The aim of this study was to discuss HIF-la expression and vasculogenic mimicry （VM） in hepatocel- lular carcinoma （HCC） and their relationship with the clinical pathological features and clinical significance. Methods： Two hundred and seven specimens from patients in The Affiliated Hospital of North Sichuan Medical College who received hepatic cell carcinoma resection were tested by immunohistochemistry and double staining of CD31 and PSA. Then detected the expression of HIF-la, VM, and analysed the relationship between clinical pathology. Results： The HIF-la positive rate was 71.01% and its expression was associated with liver cirrhosis, tumor size and TNM stage （P 〈 0.05）. HIF-la protein expres- sion was positively associated with the VM （y = 0.1988, P = 0.0041）. Conclusion： Hypoxia may be the reason for VM in high invasive HCC, regulating the tumor microenvironment may have great significance in inhibiting invasion and metastasis of HCC.
基金
Supported by a grant from Key Breeding Project of North Sichuan Medical College(No.CBY11-A-ZP16)
