银杏叶有效成分抗脑缺血再灌注损伤作用的机制研究进展

The Mechanism of the Constituents of Ginkgo Biloba against Cerebral Ischemia Reperfusion-Injury——A Literature Review

银杏叶的有效成分具有扩张血管、改善微循环、清除自由基、缓解平滑肌痉挛、抗过敏、抗菌等药理作用,有关银杏叶中的有效物质对脑缺血再灌注损伤的相关研究也日益增多,具有保护作用的主要物质基础为黄酮类及内酯类成分。本文针对国内外相关文献资料进行分析、整理和归纳,综述了银杏叶有效成分对脑缺血再灌注损伤的药理作用及机制,以及治疗脑中风的前景。

The chemical constituents of Ginkgo can help dilating blood vessels,improving microcirculation,eliminating free radicals,relieving muscle spasm,preventing allergies,inhibiting bacterial growth and so on. Furthermore,there are more and more related researches in cerebral ischemia reperfusion injury about the active principle of Ginkgo. The essential components of Ginkgo Biloba which can protect the nerves of cerebrovascular are flavonoids and lactones. Among all of these chemical constituents,lactones will cure the cerebral ischemia diseases which have been put into the design of new drugs in our country. This article aims at analyzing and concluding the information from both international and domestic literatures. The purpose of this review is to sum up the pharmacological effects and mechanisms of the bilobalide in cerebral ischemia injury and the prospect in treating stroking.