马齿苋多糖对溃疡性结肠炎相关性结肠癌IL-6/STAT3信号通路的影响

Effect of Purslane Polysaccharide on Ulcerative Colitis Associated Colorectal Cancer and IL-6 / STAT3 Pathway

最新研究报道,慢性炎症是导致肿瘤发生、发展的重要因素。结肠、直肠的慢性炎症导致炎症局部组织发生反复的损伤、修复、增生,最终引起癌变。因此,研究如何干预慢性炎症癌变成为降低结直肠癌的发生的重要方法。本文探讨马齿苋对肠道炎症及肿瘤发生、发展的影响,及其与IL-6/STAT3通路的关系。为预防炎症性肠病癌变,提供新的研究思路。

Latest reports showed that chronic inflammation is an important factor leading to tumors. Chronic inflammation of the colon and rectum would lead to repeated damage,repair and proliferation of the local tissues in inflammation area,and eventually cause cancer. Therefore,finding out how to intervene the chronic inflammation so as to decrease the occurrence of colorectal cancer has become an important method. This article explored the effects of purslane on intestinal inflammation,occurrence and development of tumor,as well as its relation to IL-6 / STAT3 pathway. It provided new research ideas to the prevention of inflammatory bowel diseases.