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关节软骨细胞生物学特征的分子调节及其发生机制研究进展 被引量：1

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摘要 关节软骨是略带弹性的坚韧组织,在机体内起支持和保护作用。关节软骨由软骨细胞、纤维和基质构成。很多关节疾病都是由于软骨损伤所造成,如半月板损伤、退行性关节炎、骨质增生、腰椎间盘突出等。软骨细胞分化过程的不同时期中软骨细胞的新陈代谢会发生相应变化,而软骨的分化过程受不同分子调节,目前已证实一些细胞因子如转化生长因子-β（transforming growth factor-β1,TGF-β）、骨形态发生蛋白（bone morpho-genetic protein,BMP）、成纤维细胞生长因子（fibroblast growth factor,FGF）、胰岛素样生长因子（insulin-like growth factors,IGF）、
作者 倪胜辉 郭磊
机构地区 中国医科大学附属第一医院骨科
出处 《中国骨与关节外科》 2013年第5期457-460,共4页 Chinese Journal of Bone and Joint Surgery
基金 国家自然科学基金(81071460 81271996)
关键词 关节软骨 分子调节 细胞生物学特征 成纤维细胞生长因子 转化生长因子-Β 胰岛素样生长因子 骨形态发生蛋白 protein
分类号 R684 [医药卫生—骨科学]
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参考文献33

  • 1于方,俞猛,付胜良.转化生长因子-β、碱性成纤维生长因子和血小板衍生生长因子在大鼠骨折愈合中的表达[J].中国骨与关节外科,2009,2(3):233-239. 被引量：10
  • 2江建明,梁鹏展,刘传芳,孙炜.转化生长因子β对白介素-1β诱导人骨关节炎软骨细胞表达NO的影响[J].中国骨与关节外科,2008,1(1):35-39. 被引量：4
  • 3Kim M, Erickson IE, Choudhury M, et al. Transient exposure to TGF-β3 improves the functional chondrogenesis of MSC- laden hyaluronic acid hydrogels. J Mech Behav Biomed Mater, 2012, 11(1): 92-101.
  • 4Xu T, Wu M, Feng J, et al. RhoAlRho kinase signaling regulates transforming growth factor- β 1- induced chondrogenesis and actin organization of synovium- derived mesenchymal stem cells through interaction with the Smad pathway. IntI Mol Med, 2012, 30(5): 1119-1125.
  • 5Longobardi L, Li T, Myers TJ, et al. TGF-β type II receptor/ MCP- 5 axis: at the crossroad between joint and growth plate development. Dev Cell, 2012, 23(1): 71-81.
  • 6Ying B, Chen K, Hu J, et al. Effect of different doses of transforming growth factor- β (1) on cartilage and subchondral bone in osteoarthritic temporomandibular joints. Br J Oral Maxillofac Surg, 2013, 51(3): 241-246.
  • 7Jeong CG, Zhang H, Hollister SJ. Three-dimensional polycaprolactone scaffold- conjugated bone morphogenetic protein- 2 promotes cartilage regeneration from primary chondrocytes in vitro and in vivo without accelerated endochondral ossification. J Biomed Mater Res A, 2012, 100(8): 2088-2096.
  • 8Jung MR, Shim IK, Chung HJ, et al. Local BMP- 7 release from a PLGA scaffolding- matrix for the repair of osteochondral defects in rabbits. J Control Release, 2012, 162 (3): 485-491.
  • 9Dorman LJ, Tucci M, Benghuzzi H. In vitro effects of bmp- 2, bmp- 7, and bmp-13 on proliferation and differentation of mouse mesenchymal stem cells. Biomed Sci Instrum, 2012, 48(1): 81-87.
  • 10Pan Q, Yu Y, Chen Q, Li C, et al. Sox9, a key transcription factor of bone morphogenetic protein- 2- induced chondrogenesis, is activated through BMP pathway and a CCAAT box in the proximal promoter. J Cell Physiol, 2008, 217(1): 228-241.

二级参考文献17

  • 1李美荣,王美美.骨关节炎患者血清和关节液一氧化氮及其合成酶变化的意义[J].安徽医药,2005,9(2):108-109. 被引量：16
  • 2Jose U. Scher MD,Michael H. Pillinger MD,Steven B. Abramson MD.Nitric oxide synthases and osteoarthritis[J]. Current Rheumatology Reports . 2007 (1)
  • 3K. Vuolteenaho,T. Moilanen,U. Jalonen,A. Lahti,R. Nieminen,H. M. van Beuningen,P. M. van der Kraan,E. Moilanen.TGFβ inhibits IL-1 -induced iNOS expression and NO production in immortalized chondrocytes[J]. Inflammation Research . 2005 (10)
  • 4M.-P. Verdier,S. Seité,K. Guntzer,J.-P. Pujol,K. Boumédiène.Immunohistochemical analysis of transforming growth factor beta isoforms and their receptors in human cartilage from normal and osteoarthritic femoral heads[J]. Rheumatology International . 2005 (2)
  • 5Hu Dan-Ning,,Yang Pey-Yuh,Ku Ming-Chou,et al.Isolation and cultivation of human articular hondrocytes. Kaohsiung Med Sci . 2002
  • 6K Vuolteenaho,T Moilanen,RG Knowles,E Moilanen.The role of nitric oxide in osteoarthritis. Scandinavian Journal of Rheumatology . 2007
  • 7Scher JU,Pillinger MH,Abramson SB.Nitric oxidesynthases and osteoarthritis. Current Rheumatology Reports . 2007
  • 8Vuolteenahol K,Moilanenl T,Jalonenl U.TGFb inhibits IL-1-induced iNOS expression and NO production in immortalized chondrocytes. Infl ammation Research . 2005
  • 9Studer RK,Georgescu HI,Miller LA,et al.Inhibition of transforming growth factor βproduction by nitric oxide-treated chondrocytes. Arthritis and Rheumatism . 1999
  • 10Harvey,A. K.,Hrubey,P. S.,Chandrasekhar,S.Transforming growth factor-beta inhibition of interleukin-1 activity involves down-regulation of interleukin-1 receptors on chondrocytes. Experimental Cell Research . 1991

共引文献12

同被引文献15

  • 1Shukunami C, Oshima Y, Hiraki Y. Chondromodulin - 1 and tenomod- ulin : a new class of tissue - specific angiogenesis inhibitors found in hy- povascular connective tissues [ J 1. Biochem Biophys Res Commun, 2005,333(2) : 299 -307.
  • 2Miura S, Kondo J, Kawakami T, et al. Synthetic disulfide - bridged cy- clic peptides mimic the anti - angiogenic actions of chondromodulin - I [J]. CancerSci, 2012,103(7) :1311-1318.
  • 3Fujii M, Furumatsu T, Yokoyama Y, et al. Cbondrmnodulin - I de- rived from the inner meniscus prevents endothelial cell proliferation[ J]. J Orthop Res, 2012,31 (4) :538 -543.
  • 4Zhou H, Kepa JK, Siegel D, et al. Benzene metabolite hydroquinone up- regulates ehondrodulin- I and inhibits tube formation in human bone marrow endothelial cells[J]. Mol Pharmacol, 2009,76(3) :579 -587.
  • 5Yoshioka M, Yuasa S, Matsumura K, et al. Chondromodulin - I main- tains cardiac valvular function by preventing angiogenesis[ J]. J Cardi- ol, 2006,47(2) :100 - 101.
  • 6Shukunami C, Takimoto A, Miura S, et al. Chondromodulin - I and tenomodulin are differentially expressed in the avaseular mesenehyme during mouse and chick development [ J ]. Cell Tissue Res, 2008,332 (1) :111 -122.
  • 7Funaki H, Sawaguchi S, Yaoeda K, et al. Expression and localization of angiogenic inhibitory factor, chondromodulin - I, in adult rat eye [J]. Invest Ophthalmol Vis Sci, 2001,42(6) :1193 -1200.
  • 8Aoyama T, Okamoto T, Nagayama S, et al. Expression of the chondro- modulin- I gene in chondresarcomas[ J]. Cancer Lett, 2004,204( 1 ) : 61 - 68.
  • 9Miura S, Kondo J, Takimoto A, et al. The N - terminal cleavage of chon- dromodulin- I in growth -plate cartilage at the hypertrophic and calcified zones during bone development[ J]. PLoS One, 2014,9(4) :e94239.
  • 10Seidah NG, Prat A. The biology and therapeutic targeting of the pmpro- rein eonvertases[ J ]. Nat Rev Drug Diseov, 2012,11 (5) :367 - 383.

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中国骨与关节外科
2013年 第5期

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