慢性肝病“肝肾精虚”证的客观量化标准

Objective and Quantitative Study on the Syndrome of "Liver-Kidney Essence Deficiency" in Chronic Liver Diseases

目的:建立慢性肝病"肝肾精虚"证的客观量化指标体系与诊疗标准,提高中医药防治慢性肝病的诊疗水平、临床疗效和服务能力。方法:采用肝损伤与肝再生的现代生物学指标作为考察"肝肾精虚"证的客观量化指标,使"肝肾精虚"的"隐性证候"成为可以准确把握的"显性证候"。结果:建立以肝脏组织学损伤、肝功能减退、再生障碍或紊乱等生物学指标为基础的"肝肾精虚"证的客观量化指标体系及诊疗标准,据此对慢性肝病"肝肾精虚"证的演变规律进行动态监测,判断预后和指导辨证论治。结论:慢性肝病"肝肾精虚"证的客观量化研究是提高中医药防治慢性肝病的诊疗水平、临床疗效和服务能力的有效途径和方法,值得进一步深入研究。

This study was aimed to establish an objective and quantitative index system and standards of diag-nosis and treatment on the syndrome of ＂liver-kidney essence deficiency＂ for chronic liver diseases , in order to improve the level of diagnosis and treatment , clinical efficacy and service capabilities in the prevention and treatment of chronic liver diseases in traditional Chinese medicine （ TCM ） . Modern biological indicators of liver damage and liver regeneration were used as objective and quantitative indicators to study the syndrome of ＂liv-er-kidney essence deficiency .＂ And the syndrome of ＂liver-kidney essence deficiency ,＂ which was used to be considered as a ＂recessive syndrome＂, was finally turning into a ＂dominant syndrome .＂ Hence , the symptom i-dentification can be accurate . The establishment of an objective and quantitative index system and standards of diagnosis and treatment of ＂liver-kidney essence deficiency ,＂ which was based on biological indicators such as indicators of histological damage in liver , indicators of hypohepatia , indicators of aregeneratory and indicators of liver dysfunction . According to all indicators , a dynamic monitoring was given on the development law of the syndrome of ＂liver-kidney essence deficiency .＂ All indicators provided references for the prognosis determina-tion and syndrome differentiation . It was concluded that the objective and quantitative research on the syn-drome of ＂liver-kidney essence deficiency＂ in chronic liver diseases is an effective way to improve the level of diagnosis and treatment, clinical efficacy and service capabilities in the prevention and treatment of chronic liver diseases in TCM , which is worth further study .