多种方法造模动物模型证属性判定逻辑问题剖析

Logic Problem Analysis on Determination of Syndrome-attribution in A Variety of Animal Model Establishment Methods

采用中医的病因造模是目前最为常用且容易判定模型动物证属性的方法。该法的根本问题是把大自然的风寒湿等与临床借助患者的异常表现抽象出风寒湿证混为一谈,常用风吹、低温冷冻、冷水浸泡和增加环境湿度等复制证的动物模型则是此类研究的典型代表。化学药品和器官切除等现代医学方法造模,则以现代医学的理化检测指标评价造模动物证的属性,是学术界较早使用的造模方法之一,但该法建造的模型本身即是一种疾病模型,将其以某些客观检测指标的异常变化做出证属性的判定,缺乏充分的理论和临床依据,应当对此类动物模型的证属性重新评价。

Intervening animals by pathogen of traditional Chinese medicine （TCM） to establish animal model is the most common and easiest method to determine syndrome attribute of an animal model. However, the underlying prob-lem of this modeling method is that the concept of wind, cold and dampness in the nature are confused with the syn-drome of wind-cold-dampness summarized by abnormal appearance of clinical patients. The typical animal model establishment are through the methods of wind blowing, low temperature freezing, cold water immersion, environmen-tal humidity increasing. Modern medical modeling methods, such as chemicals, organ resections, are also used in the establishment of animal models. Then, the syndrome-attribution of modeling animal is evaluated by physicochemical indexes of modern medicine which is one of modeling methods that have been used by academia in early times. But animal model established by this method is a kind of disease model which is lack of sufficient theoretical and clini-cal evidences. Therefore, the syndrome-attribution should be reappraised among this kind of animal models.